摘要
目的 通过测定骨代谢生化指标 ,更好地预测老年髋部骨折发生的危险性。 方法对 32例 (男 14例 ,女 18例 ) 6 0岁以上髋部骨折患者和 30例 (男 15例 ,女 15例 )老年健康对照组进行尿Ⅰ型胶原羟基末端肽 (typeⅠcollagencrosslinkedc -telopeptide ,CrosslapsTM)、脱氧吡啶啉 (deoxy pyridinoline,Dpd)和血清骨钙素 (osteocalcin ,OC或boneglaprotein ,BGP)测定。 结果 (1)老年髋部骨折患者尿中CrosslapsTM 和Dpd水平均高于对照组 (P <0 .0 1和P <0 .0 0 1) ,且对照组女性高于对照组男性 ,测定效果Dpd优于CrosslapsTM 。 (2 )老年髋部骨折患者 ,骨折后 1个月Dpd变化不大。(3)老年髋部骨折组与对照组比较 ,血清BGP水平差异无显著性意义 (P >0 .0 5 )。 结论 老年髋部骨折患者骨吸收高于同年龄组健康人。尿中反映骨吸收指标CrosslapsTM
Objective To observe the bone turnover rate of the aged patients with hip fracture by the biochemical maker for prediction of the risk of future fracture. Methods Thirty two patients (over 60 years) with hip fracture (14 males and 18 females) and 30 healthy persons (15 males and 15 females) were selected for analyzing crosslaps TM , deoxypyridinoline(Dpd) in urine,and osteocalcin (OC or BGP) in serum. Results (1)The mean urine level of crosslaps TM , Dpd in hip fracture group was significantly higher than that of control groups ( P <0.01, P <0.001 respectively), and Dpd was better than crosslaps TM . The marker of female was higher than that of male in control groups.(2) One month after fracture, there was no obvious change for Dpd.(3)The mean serum level of BGP in hip fracture was not obviously different with control groups (P >0.05). Conclusions Bone resorbtion in the aged patients with hip fracture was higher than the other same old healthy persons. It is suggested that the analysis of Dpd and crosslaps TM in urine may provide some reference value for the prevention and treatment of the aged patients with hip fracture.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2001年第6期350-352,共3页
Chinese Journal of Trauma
