摘要
目的 探讨肿瘤内毛细血管间距 (ICD)和增殖细胞核抗原 (PCNA)与宫颈癌放射敏感性的关系。方法 采用回顾性研究的方法 ,运用免疫组织化学技术和计算机图像分析方法测定 112例单纯放射治疗并随访 5年以上宫颈癌患者的PCNA表达和ICD值。结果 本组所有病例均有PCNA表达 ,PCNA指数分布在 0 .2 41～ 0 .90 3之间 ,平均为 0 .5 42 ;ICD值在 5 8.47～ 2 43.6 2 μm之间 ,平均为180 .42 μm。 结论 本研究表明PCNA的表达和ICD值与宫颈癌的放射敏感性有关 ,为寻找能预测宫颈癌放射敏感性的肿瘤标志物。
Objective To investigate the correlationship between proliferating cell nuclear antigen (PCNA), intercapillary distance (ICD) and radiosensitivity in uterine cervical cancer. Methods 112 patients who received radiotherapy alone were followed over five years. All PCNA expressions and ICD values were analyzed with immunohistochemistry assay and computer defined capillary images. Results PCNA expression was observed in all patients with the average index of 0.542 ranging from 0.241 to 0.903 um. ICD averaged 180.42 um (ranging from 58.47 to 243.62 um). Conclusions The PCNA expression and ICD value, being closely correlated with radiosensitivity and response to therapy, can be useful as markers for prediction and selection of treatment decision for uterine cervical cancer.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2001年第2期122-125,F002,共5页
Chinese Journal of Radiation Oncology
关键词
增殖细胞核抗原
毛细血管间距
宫颈癌
放射敏感性
Proliferating cell nuclear antigen
Intercapillary distance
Cervical cancer
Radiosensitivity
