摘要
目的 分析X射线立体定向放射治疗 (SRS)配合全脑照射治疗脑转移瘤的作用。方法 对 5 5例脑转移瘤患者进行SRS配合全脑照射 ,17例行单纯SRS治疗。全脑照射采用 8MVX射线 ,1.5～ 2 .0Gy/次 ,DT30～ 42Gy ,4～ 5周 ;SRS处方剂量为 18～ 30Gy,SRS前行全脑放射治疗 39例 ,SRS后行全脑放射治疗 16例。结果 SRS加全脑照射组病变完全消失 (CR)占 6 0 .0 % ,部分消失 (PR)占32 .7% ,无变化 (NC)占 7.3% ,总缓解率 (CR +PR)为 92 .7% ;与单纯SRS组的 35 .0 %、41.2 %、2 3.5 %、76 .2 %相比差异无显著性意义 (χ2 =3.47,P >0 .0 5 )。SRS加全脑照射组复发率为 14.5 % ,中位复发时间为 10个月 ,中位生存时间为 13个月 ;与单纯SRS组的 41.2 %、4个月、7.5个月相比差异有显著性意义 (χ2 =5 .5 8、t=11.1、t=7.2 7,P <0 .0 5 )。两组 1年生存情况差异无显著性意义 (χ2 =1.33,P >0 .0 5 )。结论 SRS配合全脑放射治疗脑转移瘤对减少肿瘤复发率、延缓中位复发时间。
Objective To analyse the impact of combined regimen of total brain irradiation (TBR) and X ray stereotactic were 10 months, 14.5% (8/55) and 13 months in the SRS plus TBR group, as compared with 4 months ,41.2% (7/17) and 7.5 months in the S radiosurgery (X knife,SRS) on brain metastases. Methods From October, 1997 to December, 1999, 55 patients with brain metastases were treated by SRS plus TBR and 17 patients by SRS alone. The dose of TBR was 30～42Gy/4～5 weeks, 1.5～2.0 Gy per fraction and that of SRS 18～30Gy. Results The overall response rates (CR+PR) were 92.7% in the TBR plus SRS group , and 76.2% in the SRS alone group with significant difference (P>0.05). The median recurrent period , recurrent rate and median survival period were 10 months,14.5%(8/55) and 13 months in the TBR plus SRS group, as compared with 4 month's,41.2%(7/17) and 7.5 months in the RS alone group (P<0.05). The differences approached only near to statistical significance. The 1 year survival and mortality rates were 63.6%, 36.4% and 41.7%,52.9% in the above groups (P>0.05). Conclusions For brain metastases, irradiation of the entire intracranial contents combined with stereotactic radiosurgey (X knife) has a significant impact on improving the local contol and ultimate outcome.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2001年第2期112-114,共3页
Chinese Journal of Radiation Oncology
关键词
脑肿瘤
放射治疗
X射线立体定向术
脑转移瘤
SRS
Brain neoplasms/ radiotherapy
Brain neoplasms/X ray stereotactic radiosurgery
Metastatic neoplasms, brain
