摘要
目的对颅内肿瘤单次大剂量立体定向放射治疗后产生脑水肿的有关因素作初步探讨。材料与方法回顾性分析８６例颅内病变治疗后临床及ＣＴ／ＭＲＩ发生脑水肿与剂量、容积、肿瘤部位的关系。结果随访１～１６个月（中位９个月）。限光筒直径≥２．５ｃｍ组与＜２．５ｃｍ组脑水肿发生率分别为４２．２％、２．４％（Ｐ＜０．００５）；等中心剂量≥２０Ｇｙ与＜２０Ｇｙ组分别为２７．７％和９．５％（Ｐ＞０．０５）；脑实质内肿瘤与颅底肿瘤分别为３４．８％和１０．０％（Ｐ＜０．００５）。结论颅内肿瘤单次大剂量立体定向放疗限光筒直径＜２．５ｃｍ，剂量＜２０Ｇｙ，肿瘤位于颅底部位，发生脑水肿危险性小。
Purpose To evaluate the brain edema after singledose stereotactic irradiation for intracranical tumor.Materials and Methods Clinical and CT/MRI observation of brain edema in 86 patients with brain tumor treated with singledose stereotactic irradiation was retrospectively analyzed to find out the relationships among the incidences of radiation induced brain edema and radiation volumn,dose or tumor location.Results The incidences of brain edema were:42.2% in ≥ 2.5cm and 2.4% in <2.5cm diameters of radiation fields (P<0.005);27.7% in ≥ 20Gy and 9.5% <20Gy isocenter doses;(P>0.01); 34.8% for intraparenchymal lesion and 10.0% for skull base tumor (P<0.005).Conclusion The risk would be diminished if the radiation collimator was < 2.5cm, brain isocenter dose was < 20Gy, tumor located in skull base for brain tumor treated with singledose stereotactic irradiation.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
1998年第2期109-111,共3页
Chinese Journal of Radiation Oncology
关键词
脑肿瘤
放射疗法
放射损伤
脑水肿
因素分析
Brain neoplasms/radiotherapy Stereotactic irradiation Radiation injury Bain edema
