摘要
目的通过对mmp_2与nm23两者在HBsAg阳性的二期原发性肝细胞癌中的表达及意义的研究 ,对我国原发性肝细胞癌发展与转归做进一步的了解。方法对nm23、mmp_2在二期原发性肝细胞癌组织中的表达进行免疫组化检查 ,并将检测结果进行统计分析,术后随访生存不足8个月的为预后差组(13例) ,反之 ,为预后好组(17例)。结果mmp_2与nm23在预后好组病人中 ,表达为阴性、弱阳性、阳性、强阳性分别为1/17、6/17、10/17、0/17 ;1/17、6/17、4/17、6/17 ;mmp_2与nm23在预后差组病人中 ,表达为阴性、弱阳性、阳性、强阳性分别为0/13、2/13、4/13、7/13 ;0/13、9/13、4/13、0/13。nm23、mmp_2在二期原发性肝细胞癌组织中的表达中有统计学差异。结论虽然两者对HBsAg 阳性的二期原发性肝细胞癌的术后癌转移都有预示作用 ,但mmp_2在HBsAg
Objective To study whether mmp-2 and nm23 have correlation, or which one is more important to the tumour prognosis in primary hepatocellular carcinoma(PHC). Methods Samples from 30 patients operated for primary hepatocellular carcinoma of HBsAg positive,who had suffered liver cirrhosis, were analysed by using immunohistochemistry.The patients,who survive over 8 months after operation,were better prognosis group. Those, dead in 8 months after operation, were worse prognosis group. All patients were Ⅱstage. Results 30 cases tumour tissues were tested.Among the better prognosis patients (17 cases),expression of mmp-2 was 10/17 positive stained, 6/17 mild positive stained, 1/17 negtive stained; expression of nm23 was 1/17 negtive stained ,6/17 cases mild positive stained,4/17 positive stained, 6/17 strong positive stained. Among the worse prognosis patients (13 cases), expression of mmp-2 was 4/13 positive stained, 2/13 mild positive stained, 7/13 strong positive stained; expression of nm23 was 9/13 mild positive stained, 4/13 positive stained. Conclusion Although expression of nm23 and expression of mmp-2 have relation with metastasis of these patients, but criterion on prognosis of the patients of PHC,who still suffered from liver cirrhosis, expression of mmp-2 is better than nm23's.
