摘要
对环氧合酶 -2选择性抑制剂罗非昔布 (Rofecoxib)进行了结构修饰 ,以对甲磺酰基苯乙酮为原料 ,经过溴化得到溴酮 ,然后与环己基乙酸钠在室温下反应 ,得到环己基乙酸酯 ,后者在避光、碱存在下环合得到了新化合物 4 -[4 -(甲磺酰基 )苯基 ]-3 -环己基 -2 (5H)呋喃酮。目标产物结构经 IR和 1 H
As a COX 2 selective inhibitor, Rofecoxibs structure was modified. Starting from 4 (methylsulfonyl) acetophenone, the phenacyl bromide([ST5HZ]3) was obtained through bromination, which was condensed with cyclohexylacetic acid sodium salt in DMF, giving the cyclohexylacetic ether([ST5HZ]4). Finally, via cyclization of the compound[ST5HZ](4), the new compound, 4 [4 (methylsulfonyl)phenyl] 3 cyclohexylfuran 2(5[WT5BX]H) one was synthesized. The target molecules structure has been characterized by IR and 1H NMR.
出处
《合成化学》
CAS
CSCD
2001年第3期265-266,271,共3页
Chinese Journal of Synthetic Chemistry
