摘要
以苯胺为起始原料 ,经过酰胺化、环合、苄基化、水解、脱胺基、氧化等几步反应 ,得到产物酮基布洛芬 ,总收率 4 2 .5%。该法原料易得 ,反应条件温和 ,操作简单 ,收率较高 ,适合于工业化生产。
Ketoprofen was synthesized from anline by amidation, cyclization, benzylation, hydrolysis, deamination and oxidation with an overall yield of 42.5 %. This method has advantages of easy accessible raw materials, mild reaction conditions, convenient procedures, high yield and suitable to industrialization.
出处
《精细石油化工》
CAS
CSCD
北大核心
2001年第3期28-29,共2页
Speciality Petrochemicals
