摘要
为研究肠安冲剂 (主药 :生黄芪、杭白菊、徐长卿、煨木香、红藤 )治疗溃疡性结肠炎 (US)的机理 ,将 40只大鼠分成A、B、C、D 4组 ,并对后 3组用细胞免疫 (TNBS/乙醇 )法制成UC模型 ,自造摸次日起分别给予不同方法治疗 :A、B组不予治疗 ,仅以 2ml生理盐水灌胃 ,C组 2ml固本益肠片水溶液 (药物含量 0 5 12g/ml)灌胃 ,D以 2ml肠安冲剂水溶液 (药物含量lg/ml)灌胃 ,每日 1次。 10d后观察疗效。结果 :A组各项指标均无变化 ,B组体重明显减轻、大便次数增多并成血性 ;外周血T淋巴细胞亚群紊乱、SOD活力下降、MDA含量增高 ;镜检见结肠有多个溃疡面和出血点 (与A组比较 ,P <0 .0 5～ 0 .0 1)。C组和D组大鼠的各种症状明显减轻 ,T淋巴细胞亚群趋以正常 ,抗氧化能力提高 ,镜检结肠溃疡与出血点减少 ,且D组优于C组 (P <0 .0 1)
In order to study the mechanism of 'Intestine Peace Granules'(main ingredients:Radix Astragali,Flos Chrysanthemi,Radix Cynanchi Paniculati,Radix Aucklandiae,Caulis Sargentodoxae)in treating ulcerous colitis(UC),40 rats were divided into four groups of A,B,C and D,with UC model created in the latter three groups by cellular immunity(TNBS/alcohol),and treated with different methods since the second day of the model creation.Group A and B were not treated and just fed with 2ml physiological saline into the stomach,and Group C was treated by pouring 2ml 'Anti Pathogenic Ability Supporting and Intestine Benefiting Solution'(drug content 0 512g/ml)into the stomach and Group D by pouring solution of'Intestine Peace Granules'(drug content Ig/ml)into the stomach,once a day,to observe the therapeutic effect 10 days later.The results showed that no changes took place in various indexes in Group A,and body weight decreased obviously in Group B,with increased times in defecation and blood stool,disturbance of peripheral T lymphocyte subgroup,decreased SOD activity and elevated MDA content.The colonoscope showed that were several ulcerative surfaces and bleeding spots in the colon(P< 0.05 ～ 0.01 in comparison with Group A).Various symptoms in the rats in Group C and D decreased obviously,with normal tendency of T lymphocyte subgroup and elevated antioxidation,decreased ulcers and bleeding spots in the colonoscope examination,and Group D better than Group C (P< 0.01 ).
出处
《上海中医药大学学报》
CAS
2001年第2期46-48,共3页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
上海市教委科技基金资助项目 ( 96 -C15 )
