摘要
为研究解脲尿枝原体 (UU)的耐药情况 ,指导临床合理用药 ,采用 UU培养和药敏试验盒测定 10种抗生素对 36例 UU的体外抗菌作用。结果 ,10种抗生素总的耐药发生率为 94.44 % (34 / 36 ) ,耐药 2种及 2种以上者 6 9.44 %。耐药率最高的为红霉素 5 8.33% (2 1/ 36 ) ,其次为米诺环素 5 2 .78% (19/ 36 )、四环素33.33% (12 / 36 )、螺旋霉素 33.33% (12 / 36 )和氧氟沙星 30 .5 6 % (11/ 36 )。其中螺旋霉素、红霉素和米诺环素有用药史者明显高于无用药史者 ,差异有显著意义 (P<0 .0 5 )。 10种抗生素发生耐药在病程 >半年组与≤半年组间无显著差异 (P>0 .0 5 )。女性患者四环素与螺旋霉素耐药发生率明显高于男性患者 (P<0 .0 5 )。交沙霉素、阿奇霉素、罗红霉素、多西环素和左氧氟沙星显示了良好的敏感性。提示 UU耐药发生率高 。
Objective: To study the status of drug resistance of Ureaplasma urealyticum (UU) and instruct justifiable application of antibiotics clinically. Methods: Antibacterial activities of 10 antimicrobial agents against 36 cases of UU were determined using specific agent kit for UU culture and drug susceptibility test. Results: The total resistant rate was 94.44% (34/36). The resistant rate against 2 and more than 2 kinds of antibiotics was 69.44%. The highest resistant rate occurred in erythromycin which was 58.33% (21/36). The next were minocycline (52.78%, 19/36), tetracycline (33.33%, 12/36), spiramycin (33.33%, 12/36) and ofloxacin (30.56%, 11/36). UU showed higher resistant rate against spiramycin, erythromycin and minocycline in the group of those having used drugs than those of without drug history which had significant difference ( P <0.05). No obvious differences were observed between the group whose course was more than half a year and the one whose course was equal or less than half a year ( P >0.05) for all the 10 antimicrobial agents . The resistant rate against tetracycline and spiramycin in female group was higher than that of in male significantly ( P <0.05). Josamycin, azithromycin, roxithromycin, doxycycline and levofloxacin showed excellent susceptibility. Conclusion: UU showed high degree and multiple drug resistance.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2001年第3期215-217,共3页
Chinese Journal of Antibiotics
