摘要
目的 :研究转移相关基因 CD44 V6 在甲状腺癌组织中的表达及其临床意义。方法 :应用免疫组化 SP方法测定45例甲状腺癌组织中的 CD44 V6 的表达阳性率 ,分析其阳性率与肿瘤转移的关系。结果 :CD44 V6 表达阳性率在淋巴结转移组 (85 .0 % )明显高于无淋巴结转移组 (48.0 % ) (P<0 .0 5 ) ;在乳头状腺癌中的表达率为 75 .0 % ,滤泡腺癌组为 6 8.8% ,在髓样癌中及未化分癌中未见阳性表达 ;45～ 6 0岁病人组 CD44 V6 表达阳性率高于其它年龄段。分析 CD44 V6 阳性表达与临床分期的关系 ,发现随分期增加而增加 ,CD44 V6 的表达阳性率在 、 、 期分别为 6 4.3% ,77.8% ,10 0 .0 % ;死亡的 8例中有 6例 CD44 V6 表达阳性。结论 :CD44 V6 表达与甲状腺癌的颈淋巴结转移密切相关 ;与临床分期、年龄、预后及病理类型有一定关系。
Objective: To investigate the expression of CD 44V6 gene in 45 patients with thyroid carcinoma from January, 1982 to December, 1994. Methods: The expressions of CD 44V6 gene in 45 specimens of paraffin\|embedded thyroid cancer tissues and 5 thyroma and 5 normal thyroid tissue were determined by immunochemical S\|P method. There were 11 males and 34 females, ranging in age from 16 to 72 years old. The clinical stages were stages Ⅰ in 28, Ⅱ in 9, Ⅲ in 3 and Ⅳ in 5. Among 45 \ cases, 20 were lymph node metastasis and 25 non\|metastasis; pathological patterns were papillary type in 24, acinous in 16, medullary in 1 and non\|differential in 4. Results: The positive rate of expression of CD 44V6 gene was 85 0% (17/20) in group of lymph node metastasis, 48 0% (12/25) in group of non\|metastasis (x 2=4 27,\%P\%<0 05);75 0%(18/24) in group of papillary carcinoma, 68 8%(11/16) in group of acinous carcinoma. The expression of CD 44V6 was negative in the groups of medullary (1 case), non\|differential carcinoma (4 cases) and thyroma (5 cases) and normal tissue of thyroid (5 cases). The positive rate of CD 44V6 was 64 3%, 77 8% and 100 0% in the clinical stages Ⅰ,Ⅱ and Ⅲ, respectively. Among 8 cases who died, 6 cases were positive of CD 44V6 . Conclusion: The results suggested that the expressions of CD 44V6 were closely correlated with lymph node metastasis, clinical stages, prognosis and pathological patterns.
出处
《耳鼻咽喉（头颈外科）》
2001年第3期164-166,共3页
Chinese Arch Otolaryngology-Head Neck Surg
