摘要
目的:研究子宫内膜异位症(EM)患者在位和异位内膜粘附分子CD44拼构变异体6(CD44v6)、细胞间粘附分子-1(ICAM-1)和细胞钙粘附素E(E-cadherin)表达及其在EM发病机制中的作用。方法:采用S-P免疫组化染色法对30例子宫内膜异位症患者的异位内膜、在位内膜与30例正常子宫内膜进行CD44v6、ICAM-1和E-cadherin检测。结果:①异位内膜组CD44v6、ICAM-1表达明显升高,差异有统计学意义(P<0.05),E-cadherin表达明显降低,差异有统计学意义(P<0.05);②在位内膜组CD44v6、ICAM-1和E-cadherin表达明显降低,差异有统计学意义(P<0.05)。结论:CD44v6、ICAM-1、E-cadherin和子宫内膜异位症的发生发展密切相关。
Objective ： To study the expressions of CD44v6, ICAM - 1 and E - cadherin in ectopic endometrium and eutopic endo- metrium of endometriosis and their roles in pathogenesis of endometriosis. Methods ： The expression levels of CD44v6, ICAM - 1 and E - cadherin from ectopic endometrium and eutopic endometrium in 30 cases with endometriosis and normal endometrium from 30 cases without endometriosis were detected by immunohistochemical SP method. Results ： The expression levels of CD44v6 and ICAM - 1 in ectopie endo- metrium group increased significantly （ P 〈 0. 05 ）, the expression level of E - eadherin in eetopie endometrium group decreased significantly （ P 〈 0. 05 ） ; the expression levels of CD44v6, ICAM - 1 and E - eadherin in eutopie endometrium group decreased significantly （ P 〈 0. 05 ） Conclusion ： CIM4v6, ICAM - 1 and E - eadherin are related to oncogenesis and development of endometriosis closely.
出处
《中国妇幼保健》
CAS
北大核心
2010年第15期2135-2137,共3页
Maternal and Child Health Care of China
基金
温州市科技局资助项目〔Y20080119〕
