摘要
目的 用染色体畸变分析方法对河南“4 2 6”6 0 Co辐射事故 7例受照者 ,进行了早期生物剂量估算。方法 照后 4～ 5d取血培养 ,分析第一次有丝分裂细胞“双 +环”畸变率 ,并由此估算生物剂量。用“双 +环”畸变在细胞间的泊松分布情况 ,检验照射的均匀性。结果 7例受照者依据“双 +环”畸变率估算的个体辐射剂量分别为 5 0 9Gy(梅 )、2 6 1Gy(天 )、2 49Gy(旺 )、0 89Gy(勇 )、0 70Gy(民 )、0 5 8Gy(义 )和 0 0 8Gy(宇 ) ,与用物理方法测定的剂量比较接近 ,亦与放射损伤的临床诊断完全吻合。泊松分布检验证实 ,“梅”和“旺”双 +环畸变偏离泊松分布 ,其余 5例符合泊松分布。结论 染色体畸变分析是非常可靠的生物剂量估算方法。“梅”和“旺”受到不均照射 ,其他 5例受到比较均匀的照射。
Objective Biological dose assessment was performed by chromosomal aberration analysis for seven victims exposed accidentally to 60 Co gamma|rays in Henan Province,P.R.China. Methods The individual radiation dose was estimated by the yields of dicentrics plus rings.The well|distributed exposure or non|uniform one was tested by the Poisson distribution of dic+r. Results The equivalent whole body doses for the seven victims were estimated to be 5^09 Gy(Mei),2 61 Gy(Tian),2 49 Gy(Wang),0 89 Gy (Yong),0 74 Gy (Min),0 58 Gy(Yi) and 0 08 Gy(Yu) respectively on d4/d5 after the accident.These doses were very consistent with the mean doses calculated from physical measurement and conformable to the clinical diagnosis.The dic+r aberrations of “Mei” and “Wang” did not accord with Poisson distribution,whereas those of the other 5 cases did. Conclusion The analysis of chromosomal aberrations is an extremely reliable method in biological dosimetry.The radiations which “Mei” and “Wang” were exposed to were heterogeneous while they were homogeneous for the other 5 cases.
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
2001年第3期153-155,共3页
Chinese Journal of Radiological Medicine and Protection
关键词
^60Co辐射事故
染色体畸变
生物剂量估算
Co radiation accident
Chromosomal aberrations
Biological dose assesssment
