摘要
采用聚 β 羟基丁酸酯 (PHB)与聚乙二醇 (PEG)共混物为载体材料 ,以肌苷为模型药物 ,利用W1 O W2 型复乳蒸发技术制备肌苷缓释微球 .探讨了溶剂、稳定剂、药物浓度、载体材料等因素对微球产率、包埋率及体外释放率的影响 ,并优化了微球制备条件 .实验结果表明 ,以二氯甲烷为溶剂 ,当明胶质量分数为 0 .6%、肌苷质量分数为 5%、PHB与PEG的质量比为 7 3时 ,制得的微球收率为 70 % ,包埋率为 81.6% ,且微球外观圆滑 .研究微球体外释放行为时发现 ,用上述条件制得的肌苷微球在释放的第 18小时时 ,达到了最大释放量 ,并具有明显的缓释效果 .
Inosine microspheres were prepared using the solvent evaporating method with a W1-O-W2 emulsion. Compound of poly hydroxybutyrate (PHB) and poly ethylene glycol (PEG) were used as a carrier to retard the release of inosine. The factors influencing the yield, encapsulation efficiency and release characteristics of inosine microsphere are discussed. Optimum conditions for inosine microsphere preparation involve that PHB and PEG to have a mass ratio of 7:3. The mass of gelatin and inosine is 0.6% and 5% of the total system mass, respectively. The dichloromethane is used as solvent. The yield and the encapsulation efficiency of inosine microsphere reach 70% and 81.6%, respectively. The experimental result of drug release in vitro indicates that their behavior of drug cleaned by microsphere is excellent.
出处
《西安交通大学学报》
EI
CAS
CSCD
北大核心
2001年第7期759-763,共5页
Journal of Xi'an Jiaotong University
基金
国家"八六三"计划新材料项目 (715 -0 0 4- 0 16 0 )
西安交通大学理科基础研究基金资助项目 (970 7) .
