摘要
目的 探讨术前应用免疫导向技术治疗胃癌的临床效果。方法 以应用 1 31 I -3H 11对 16例胃癌病人术前行内镜下癌灶多点注射作为治疗组 ;选择 6例胃癌病人采用FAM方案化疗作为对照组。并对术后标本进行观察。结果 术后病理检查治疗组发现 75 .0 %(12 16 )出现癌细胞核固缩、碎裂、细胞浆凝固、细胞间质出现炎性细胞浸润 ;这些变化多以中度为主 ,重度及无变化较少 ;而对照组无明显变化。结论 作为胃癌的综合治疗方法 ,术前胃癌局部注射1 31 I - 3H
Objective To investigate the effect of intratumor injection of 131 I 3H11 for gastric cancer (GC). Methods 16 patients with GC subjected to endoscopic intratumor injection of 131 I 3H11 as a treatment group; 6 GC patients with FAM chemotherapy as a control group. Histological examination of the postoperative specimens of the two group were comparated. Results In treatment group, 75.0%(12/16) of cases were found to have morphological changes with karyopyknosis, karyorrhexis, coagulation of cytoplasm, and invasion of lymphocyte in mesochyma. Most of these changes were medial; but in control group no obvious morphological change was found. Conclusions The results suggest that GC subjected to endoscopic intratumor injection of 131 I 3H11 preoperatively has promising application in the clinic.
出处
《中国普通外科杂志》
CAS
CSCD
2001年第3期202-205,共4页
China Journal of General Surgery
关键词
胃肿瘤/治疗
免疫导向疗法
注射病灶内
抗体
单克隆
STOMACH NEOPLASMS/ther
IMMUNOGULDING THERAPY
INJECTIONS,INTRALESONAL
ANTIBODIES,MONOCLONAL
