摘要
目的 探讨α 干扰素在肾癌根治术后的治疗作用。 方法 将 46例肾癌患者随机分成两组 :治疗组 2 1例肾癌根治术后应用α 干扰素治疗 ,对照组 2 5例单纯行肾癌根治术。 结果 治疗组T淋巴细胞亚群CD3 、CD4 、CD8、CD4 /CD8与术前比较差别有显著性意义 (P <0 .0 5 ) ;对照组CD3 、CD4 、CD8、CD4 /CD8与术前比较差别无显著性意义 (P >0 .0 5 )。治疗组术后 3年 (90 .5 % )及 5年 (81.0 % )生存率明显高于对照组 (P <0 .0 5 )。 结论 肾癌根治术后应用α 干扰素治疗 ,有利于病人术后免疫功能恢复 ,增强机体抗肿瘤能力 ,消灭残留癌细胞 ,减少复发 。
Objective To study the effect of α interferon in the treatment of renal cell carcinoma after radical nephrectomy. Methods From Jan 1988 to Jan 1998 ,46 cases of renal cell carcinoma were randomized into two groups: the interferon group treated by radical nephrectomy and α interferon and the control group with radical nephrectomy alone. Results The T lymphocyte subsets CD 3,CD 4,CD 8,the ratio of CD 4/CD 8 were significantly different berfore and after treatment in the interferon group( P < 0.05 ), the 3 year( 90.5 %) and 5 year( 81.0 %) survival rate being higher than the control group ( P < 0.05 ). Conclusions α interferon therapy after radical nephrectomy can restore celluar immunity so as to enhance the treatment efficacy.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2001年第6期350-352,共3页
Chinese Journal of Urology
