摘要
目的 观察氟康唑预防、治疗急性白血病合并霉菌感染的疗效及其毒副作用。方法 将 112例次急性白血病患者分为两组。A组共 2 5例次 ,在化疗后外周血白细胞低于 2 .0× 10 9/L时即予常规口服氟康唑 10 0mg/d共 7d ;B组共 87例次 ,仅在白血病患者化疗后符合霉菌感染诊断标准[2 ] 情况下予静脉用氟康唑 2 0 0mg/d治疗。观察急性白血病合并霉菌感染的特点 ;并对照两组患者霉菌感染的发生率及氟康唑的毒副作用。结果 A、B两组患者中霉菌感染发生率有明显差异 (χ2 =4.2 1,P <0 .0 5 ) ;急性白血病患者易合并消化道、呼吸道及泌尿系统霉菌感染 ;氟康唑未见有严重毒副作用。结论 口服氟康唑能安全。
Objective\ To observe curative and side effects of fluconazole in preventing and treating fungal infection in patients with acute leukemia.Methods\ 112 cases patients with acute leukemia were divided into two groups.Group A was prevented group (25 cases).These patients had fluconazole by oral administration with 100 mg/d for 7 days when the peripheral white blood cell were less than 2.0×10 9/L.Group B was treated group (87 cases).These patients had intravenous drip fluconazole with 200 mg/d if they reach the fungal infection diagnosis standard.To observe the characters of fungal infection in acute leukemia,the occurrence ratio of fungal infection in these two groups and the side effects of fluconazole.Results\ The occurrence ratio of fungal infection in Group A and B had obvious difference.(χ 2=4.21,P<0.05);Patients with acute leukemia were easily infected by fungal in gastrointestinal,respiratory and urinary systems.There is no sereve side effect observed in using fluconazole.Conclusion:Taking fluconazole by oral administration can safely and effectively prevent fungal infection in patients with acute leukemia.
出处
《医师进修杂志》
北大核心
2001年第6期29-30,共2页
Journal of Postgraduates of Medicine
