摘要
目的 观察直肠癌患者手术前后T细胞亚群的变化。方法 采用单克隆抗体酶标法动态检测 46例直肠癌患者手术前后外周血T细胞亚群的表达。结果 (1)直肠癌组CD3 、CD4 阳性细胞数和CD4 /CD8比值明显低于对照组 ,CD8阳性数高于正常对照组 ;(2 )机体抗肿瘤免疫功能受抑与癌肿分期密切相关 ;(3)根治性切除术后免疫功能可逐渐恢复 ,姑息性切除、单纯造口或探查术后免疫功能持续低下。结论 直肠癌患者免疫功能的变化与癌肿负荷密切相关 ,采用T细胞亚群的动态检测对于判断肿瘤发展。
Objective\ The changes of peripheral T cell subgroup in patients with rectal cancer preoperatively and postoperatively were studied dynamicly.Method\ Peripheral T cell subgroup of 46 patients with rectal cancer was measured dynamicly by the monoclonar antibody enzyme labelling techniques during the preoperative and postoperative period.Result\ (1)CD 3 cell and CD 4 cell decreased markedly,the CD 4/CD 8 rate increased apparently in patients with rectal cancer.(2)Depressed immunity was related to the term of cancer.(3)The immunity of patients treated by radical rectal resection may recover gradually,the immunity of patients treated by palliative rectal resection,colostomy and laparotomy was depressed constantly.Conclusion\ The depressed immunity of patient with rectal cancer was related to the tumour preponderance.T cell subgroup dynamic surveillance was important to juide the possibility of recurrence and prognosis in patient with rectal cancer.
出处
《医师进修杂志》
北大核心
2001年第6期20-21,共2页
Journal of Postgraduates of Medicine
