摘要
目的 观察前列腺素E1(PGE1)对慢性重型肝炎患者血清可溶性白细胞介素 - 6受体 (SIL - 6R)及其 β链(sgp130 )的影响。方法 应用酶联免疫吸附法检测 16例慢性重型肝炎患者经PGE1治疗前后血清SIL - 6R、sgp130的动态变化。结果 慢性重型肝炎患者血清SIL - 6R、sgp130水平较健康对照组明显升高 (P <0 .0 1) ,PGE1治疗后血清SIL - 6R、sgp130水平较治疗前明显下降 (P <0 .0 1) ,且治疗组死亡率明显下降 (P <0 .0 1)。结论 监测血清SIL - 6R、sgp130水平能反映慢性重型肝炎的肝损伤程度及判定预后 ;PGE1能纠正慢性重型肝炎患者的免疫功能紊乱 。
Objective\ To observe the effect of prostaglandin E 1 on soluble interleukin-6 receptor(SIL-6R) and soluble interleukin-6 receptor β strands (sgp 130) in serum in patients with chronic severe hepatitis.Methods\ Sixteen patients with chronic severe hepatitis accepted therapy with prostaglandin E 1.Serum levels of SIL-6R and sgp130 were detected by enzyme linked immunosorbent assay (ELISA) method before and after therapy.Results\ The content of SIL-6R and sgp 130 in serum were increased significantly (P<0.001) in patients with chronic severe hepatitis compared with normal control group and decreased obviously (P<0.01) after therapy with prostaglandin E 1 compared with before therapy,and the rate of delth were decreased obviously (P<0.01) in PGE 1 therapy group.Conclusion\ The levels of SIL-6R and sgp130 in serum can reflect the degree of liver damage in patients with chronic severe hepatitis and guide the assessment of prognosis;PGE 1 can correct the immune disorder,attenuating hepatocyte inflammation and necrosis.
出处
《医师进修杂志》
北大核心
2001年第6期16-18,共3页
Journal of Postgraduates of Medicine
