摘要
目的评估准分子激光削融术（ＰＲＫ）后局部滴用艾氟龙（ｆｌｕｏｒｏｍｅｔｈｏｌｏｎｅ，ＦＭＬ）或地塞米松滴眼液（ｄｅｘａｍｅｔｈａｓｏｎｅ，ＤＥＸ）治疗后皮质类固醇性高眼压、角膜雾浊及屈光回退的发生率。方法追踪观察了ＰＲＫ治疗的１７７例患者（３４１眼）。患者自上皮愈合日始，随机分为滴０．１％艾氟龙或０．２５％地塞米松组。药物使用４次／ｄ，共１个月；从第２月始逐月每日减少１滴，总疗程４个月。随访时间分别在１０ｄ，１、２、３、４月。结果ＰＲＫ术后４月，皮质类固醇性高眼压发生率艾氟龙组为１４．８％，地塞米松组为３２．１％，差异有显著性（Ｐ＜０．０１）。角膜雾浊和屈光回退在两组间基本相似（Ｐ＞０．０５）。结论ＰＲＫ术后使用艾氟龙可有效降低皮质类固醇性高眼压的发生率，但对减轻角膜雾浊，防止屈光回退的效果两药相同。
ObjectiveTo assess the incidence of corticosteroid induced intraocular hypertension,haze and regression of refraction in topical administration of dexamethasone(DEX) or fluorometholone(FML)after PRK.MethodsThe study group consisted of 177 consecutive patients (341 eyes) undergone PRK from July to September 1995.Patients were randomly,double maskedly assigned to topical treatment with either 0.25% DEX or 0.1% FML after PRK.All treatment regimens were instituted 4 times daily for 1st mon,3 times daily for 2nd mon,2 times daily for 3rd mon,and only 1 time daily for 4th mon.The follow up studies were done in baseline,10 d,1,2,3,4 mon intervals.ResultsThe incidence of corticosteroid induced intraocular hypertension was 32.1% at DEX group,and 14.8% in the FML group ( P <0.05).The corneal haze and regression of refraction between FML group and DEX group were similar at 6 mon after PRK( P >0.05).ConclusionFML and DEX may be effective to reduce the corneal haze and the deposits of collagen.In comparison with DEX,FML give less potential risk of intraocular hypertension.
出处
《眼科研究》
CSCD
1998年第2期136-138,共3页
Chinese Ophthalmic Research
