摘要
目的 探讨次声作用对大鼠记忆功能及斜角带核和隔内侧核胆碱能神经元表达的影响。方法 记忆保持SD大鼠接受 16Hz ,90dB或 13 0dB次声照射 ,2h/次·d-1,作用 7d或 14d ,观察不同声强、不同时间次声作用对大鼠回避反应的潜伏期及隔内侧核 /斜角带核 (MS/DB)胆碱能神经元表达的影响。结果 13 0dB次声作用组大鼠记忆功能显著降低 (P <0 .0 1) ,隔内侧核和斜角带核胆碱能神经元数目明显降低 (P <0 .0 1) ,90dB组差异不明显。结论 次声作用可以导致隔内侧核和斜角带核胆碱能神经元的数目减少 ,使大鼠记忆功能下降 ,效应与次声的声强有关。声强相同时 ,14d与 7d的效应差异不显著。
Objective To explore the influence on memory function and expression of cholinergic neurons in the medial septal nucleus/nucleus of diagonal band(MS/DB) of the rats exposed to 16 Hz infrasound. Methods The SD rats with memory keeping were exposed to infrasound of 16 Hz with intensity of 90dB or 130 dB for 7,14 d and two hours every time in a day,then observed the latency of avoidance response and expression of cholinergic neurons in the MS/DB with immunohistochemical technique at the different time.Results The memory function of rats exposed to 130 dB infrasound were reduced (P< 0.01 ),the number of the cholinergic neurons in the MS/DB was decreased dramatically (P< 0.01 ) ,no difference was observed in the group exposed to 90 dB infrasound. Conclusion Infrasound can induce number of cholinergic neurons in the MS/DB decreased and memory function as well.The effects are related to the intensity and times of infrasound.When the intensity is same,the effect of 14 d group is no signifcant with 7d group.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2001年第2期79-82,共4页
Chinese Journal of Physical Medicine and Rehabilitation
基金
全军重点研究课题资助项目!(96Z0 4 2 )
关键词
次声
记忆
隔内侧核
斜角带核
大鼠
胆碱能神经元
表达
Infrasound
Memory
Medial septal nucleus
Nucleus of diagonal band
Acetyltransferases
Rats
