摘要
目的：观察异丙嗪对家兔内毒素性发热及血清超氧化物歧化酶（ＳＯＤ）和脂质过氧化物丙二醛（ＭＤＡ）含量的影响。方法：复制家兔内毒素性发热模型，用黄嘌呤氧化酶法测定血清ＳＯＤ的活性，用改良巴比妥酸微量法测定血清ＭＤＡ的含量。结果：异丙嗪不仅完全抑制内毒素性发热，而且降低正常体温，该剂量的内毒素引起发热时，血清ＳＯＤ活性和ＭＤＡ含量未见明显改变，而静脉注射异丙嗪（２５ｍｇ／ｋｇ）却引起血清ＳＯＤ活性降低（Ｐ＜００５）和ＭＤＡ含量明显升高（Ｐ＜００５）。结论：在本实验条件下，内毒素性发热时血清自由基水平未见明显改变。
AIM and METHOD:The effects of intravenous injection of endotoxin (ET) and promethazine (PMZ) on superoxide dismutase (SOD) and malondialdehyde (MDA) in serum were studied. RESULTS:PMZ not only inhibited ET-induced febrile response completely, but also caused hypothermia in rabbits.The contents of SOD and MDA in serum did not change significantly during ET-induced fever, but antioxidant PMZ increased MDA content and suppressed SOD activity in serum. CONCLUSION: ET-induced fever has no effect on free radical metabolism in rabbits serum. The mechanism by which PMZ increased the content of MDA in serum remains to be investigated further.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1998年第3期290-292,共3页
Chinese Journal of Pathophysiology
