摘要
为探讨细胞色素P4502E1(CYP2E1)基因变化与胃癌易感的关系,采用病例—对照分子流行病学研究方法和多聚酶链反应技术—限制性片段长度多态性(PCR—RFLP),对142例胃癌患者和167例正常对照者CYP2E1基因RsaⅠ酶切位点进行多态性分析。结果显示胃癌患者和正常对照人群在基因型和等位基因频率上均无显著的统计学差异;我国人群CYP2E1 RsaⅠ酶切位点多态性的分布频率与日本人群相近,与欧美人群差异较大。
To study the relatioship between the CYP2E1 gene and the susceptibility to gastric cancer, a case-control molecular epidetniological study (case = 142, control = 167) was used to compare the frequency of CYP2E1 genotype between gastric cancers and controls with a PCR -RFLP method. Result showed that there was no significant difference in frequencies of genotypes or alleles between gastric cancers and controls; the CYP2E1 Rsa I polymorphism in Chinese population was similar to that in Japanese population, and was different from that in European and American population.
出处
《中国初级卫生保健》
2001年第5期16-18,共3页
Chinese Primary Health Care
基金
江苏省卫生厅科研基金
