摘要
目的 探讨能否利用损伤的神经远端延长法修复自身缺损。方法 观察A组 (即刻快速延长 10 % )、B1组、B2组 (神经损伤 2周后再行延长 ,延长率分别为 10 %、2 0 % )神经耐受程度和恢复情况。结果 A组平均延长 (10 .0 0± 1.71) % ,长度为 (4.0 0± 0 .74)mm ,神经传导速度恢复率 (75 .71± 19.0 5 ) %、有髓神经纤维 (NNF)再生率为 (72 .60± 15 .76) % ;B1分别为 (10 .5 0±1.12 ) %、(4.2 0± 0 .44)mm、(82 .0 8± 4.76) %、 (76.2 2± 8.60 ) % ;B2组分别为 (2 1.40±4.0 3 ) %、(8.5 0± 1.61)mm、(70 .87± 2 0 .86) %、(64 .67± 12 .42 ) %。即刻延长 10 %和损伤 2周后快速延长 10 %、2 0 %都有一定功能的恢复。结论 变性周围神经的即刻延长在 10 %延长范围内耐受性好 ,而延长 2 0 %仍有再生 。
Objective To investigate the feasibility of repairing defect by segment expansion of the distal injured nerve. Methods A rabbit median nerve injury model was employed. Twenty four rabbits weighing 2.5～3.0 kg were used for stretching their wallerian degenerating median nerves with TE. Rabbits were divided into three groups: group A (the distal end of nerves were expanded about 10% immediately after injuries), group B1 (the distal end of nerves were expanded about 10% two weeks later after injuries), group B2 (the distal end of nerves were expanded about 20% two weeks later after injuries). All animals were evaluated by electrophysiological histological methods. Results The nerves were increased in length. The mean elongation was (4.00±0.74) mm with an elongation rate of (10.00 ±1.71)%, recovery rate of nerve conduction speed (75.71±19.05)% and the regenerating rate of NNF (72.60±15.76)% in group A; (4.20±0.44) mm with an elongation rate of (10.50± 1.12)%, recovery rate of nerve conduction speed (82.08±4.76)% and the regenerating rate of NNF (76.22 ± 8.60)% in group B1; (8.50±1.61) mm with an elongation rate of (21.40±4.03)%, recovery rate of nerve conduction speed (70.87±20.86)% and the regenerating rate of NNF (64.67±12.42)% in group B2. The data showed good function recovery. Conclusion The ideal range for rapid expansion of the degenerating nerve was 10%. Regeneration still existed in expansion of 20%. The method for rapid expansion of the distal injured peripheral nerve could be used to repair nerve defect.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2001年第3期253-254,共2页
Chinese Journal of Experimental Surgery
基金
国家教委回国人员启动基金!资助项目 ([1 993] 360 )
