摘要
目的观察川芎嗪对油酸性肺损伤的防治作用。方法家兔随机分成对照组、油酸组和油酸 +川芎嗪组。比较各组肺冲洗液中MDA含量和肺的湿 /干重比值。结果川芎嗪 +油酸组的血清丙二醛(MDA)含量明显低于油酸组 (P <0 .0 5 ) ,支气管肺泡灌洗液 (BALF)中的MDA、蛋白含量和肺湿重 /干重比值与对照组无明显差异 ,但显著低于油酸组 (P <0 .0 1 )。结论川芎嗪通过抗自由基损伤和膜脂质过氧化等作用 。
Objective To investigate the effects of tetramethylpraigine on experimental model of lung injury induced by oleic acid in rabbit.Methods The rabbits were randomly assigned to three groups:normal control group (NC),oleic acid group (OA),and tetramethylpraigine+oleic acid group (TMP+OA).Compare the contents of malondialdehyde (MDA) in serum,the contents of MDA and protein in broncho alveolar lavage fluid (BALF) and the wet/dry weight ratio of lung for all 3 groups.Results The MDA contents of serum were significantly lower in group TMP+OA than in group OA(P<0.05).The MDA and protein content in BALF and the wet/dry weight ratio of the lung in group TMP+OA did not change significantly as compared with group NC,but these parameters were obviously higher in group OA(P<0.01).Conclusion It suggests that TMP has preventive and therapeutic effects on lung injury induced by oleic acid in rabbits.
出处
《咸宁医学院学报》
2001年第1期23-25,共3页
Journal of Xianning Medical College
关键词
川芎嗪
油酸
丙二醛
肺损伤
成人呼吸窘迫综合征
Tetramethylpraigine
Oleic acid
Lung Injury
Malondialdehyde
Adult respiratory distress syndrome
