摘要
本文报告食管癌高发区15～25岁有癌和无癌家族史青少年人食管上皮癌前病变的对比研究。其中,有癌家族史者148人,无癌家族史者272人。前者食管上皮乳头升高,中性粒细胞浸润,不全角化,基底细胞增生和间变的发生率(%)男性为42.69、12.36、1.12,3.37和1.12;女性为32.2,8.47,1.69,5.08和0。无癌家族史青年人的发生率(%)男性为27.22,7.22,6.67,5.55和0.56;女性为28.26,10.8 6,5.43,1.67和0。有癌家族史青年人食管粘膜上皮异常发生率和乳头升高发生率明显高于无癌家族史青年人(P<0.05)。女性有癌家族史青年人基底细胞增生率高于无癌家族史青年人;提示食管癌前病变的发生有家族倾向性。
This study is the first report a bout the large-scale data on the prevalence of precancerous lesions of the esophagus from 420 with the age group from 15 to 25 in a high-risk area for esophageal cancer.Of these 148 persons are from households with an adult case of esophageal cancer and 272 persons from households without esopageal cancer.The rates of papillae upgrowth,neutrophillic granulocyte Infiltration,parakeratosis,basal cell hyperplasia and dysplasia in persons with cancer households are 42.69,12.36,1.12,3.37,1.12 (Male) and 32.2,8.47,1.69,5.08 (Female) respectively.The rates of those without cancer households are 27.22,7.22,6.67,5.55,0.56 (Male)and 28.26,10.86,5.43,1.67 (Female),respectively. The prevalence of precancerous lesions is higher in young persons with cancer housholds than that in young persons without cancer households,which indicate a hereditarycond ition disposing to esophageal cancer.
出处
《河南肿瘤学杂志》
1991年第2期14-17,共4页
Henan Journal of Oncology
关键词
食管上皮
癌前病变
有癌家族
young person's esophagus
precancerous lesions
cancer household
