摘要
目的 探讨EGFR基因蛋白在食管癌中的表达与食管癌的发生发展及浸润转移之间的关系。方法 采用免疫组织化学方法检测 58例食管癌标本中和 12 2例食管上皮其他各组病变中EGFR的表达水平及EGFR的表达与食管癌的临床病理特征关系。结果 正常组 ( 0 2 0 ,0 % )、轻度不典型增生 ( 6 32 ,18.8% )及中度不典型增生组 ( 11 19,57.9% )相邻组间EGFR表达均有显著性差异 (P<0 .0 5) ;Ⅰ级鳞癌 ( 14 2 2 ,6 3.6 % )与中 ( 11 19,57.9% )、重度不典型增生 ( 9 15,6 0 .0 % )、Barrett’s食管( 5 8,6 2 .5% )组间EGFR表达均无显著性差异 (P >0 .0 5)。高、中分化组 ( 16 39,4 1.0 % )与低分化组( 11 19,57.9% )间EGFR表达差异无显著性 (P =0 .10 86 ) ;有淋巴结转移者 ( 2 3 39,59.0 % )与无淋巴结转移者 ( 4 19,2 1.1% )相比较 ,差异有显著性 (P =0 .0 0 56 )。结论 随着肿瘤恶性程度及浸润转移的增加 ,EGFR基因蛋白表达逐渐增强 ;EGFR可作为监测肿瘤早期发生 ,预测转移潜能和预后状况的有价值的指标 ;
Objective To study the expression of EGFR in esopha ge al carcinoma and to investigate its value in development, invasion and metastasi sof the disease. Methods The expression of EGFR in 58 cases eso phageal carcinoma specimens and 122 other esophageal epithelial diseases was obs erved and the clinical pathological characteristics of the kind of of carcinoma were analyzed. Results The positive rate of EGFR was significan t different between group, low and moderate-grade atypical hyperplasia groups ( P<0.05); the was no significant difference betwee n grade Ⅰ squamous carcinoma (14/22), moderate and severe atypical hyperplasia and Barrett's esophagus (P>0.05); significant difference was found between w ell or moderate-differentiated group and poor-differentiated group (P=0.10 86). The expression of EGFR was significant between the cases with lymph node me tastasis and those without lymph node metastasis (P=0.0056). Conclus ions EGFR expression is gradually increased in esophageal carcinoma wit h the development of malignant grade and invasion; EGFR can be used as a valuabl e index for monitoring tumor early onset, predicting tumor metastasis and progno sis condition.
出处
《消化外科》
CSCD
2004年第2期105-108,共4页
Journal of Digestive Surgery
关键词
食管肿瘤
EGFR
浸润和转移
免疫组织化学
EGFR esophageal carcinoma invasion and metastas is immunohistochemistry
