摘要
目的 :报告原发于头颈部淋巴结外非霍奇金氏淋巴瘤的临床及细胞免疫学表型特点。方法 :回顾近十年来经病理学确诊的 ,原发于头颈部淋巴结外的非霍奇金氏淋巴瘤 115例 ,对其临床和细胞免疫学表型特征进行分析。结果 :本组头颈部淋巴结外非霍奇金氏淋巴瘤发病高峰年龄段为 2 1～ 40岁 ,原发部位鼻腔最多 ,其次为鼻咽、扁桃体和口腔 ,而口咽、下咽和喉较少。临床表现以原发器官症状为主 ,体征以结节状或菜花状肿块型最多 ,其次为肿块伴溃烂型 ,单纯溃烂型较少。细胞免疫学表型结果显示 ,来源于 T细胞者占 5 1.2 % ,来源于 B细胞者占 48.8%。其中鼻腔以 T细胞淋巴瘤为主 ,鼻咽则 T、B细胞淋巴瘤约各占一半 ,扁桃体和口腔则以 B细胞淋巴瘤为多。结论 :头颈部淋巴结外非霍奇金氏淋巴瘤最常原发于鼻腔 ,其次为鼻咽、扁桃体和口腔 ,临床表现缺乏特征性 ,易与原发器官的其他恶性肿瘤相混淆 ,易造成误诊 ,因此必须依据病理学和免疫组化染色进行鉴别和确诊。
Objective:To report the characteristic of clinical manifestation and cell immunophenotype in cases with primary extra nodular non Hodgkin′s lymphoma(PE NHL) in head and neck Methods One hundred and fifteen patients with PE NHL in head and neck were reviewed,which were diagnosed by pathology in the pas ten years The features of clinical manifestation and cell immunophenotype in these patients wre analyzed Results:Twenty to forty years old was most common (42 0%) ages range in the group of patients with PE NHL Nasal cavity was the most commonly involved site (36 6%,42/115), next the PE NHL respectively occurred in nasopharynx(26 1%,30/115),tonsilla(20 1%,24/115) and oral cavity (8 7%,10/115) Only in a few cases the PE NHL occurred in oroharynx,laryngopharynx and larynx The patients mainly showed the symptoms of primary lesion located The lump,ulcer or both signs were observed on primary position,the lump was the most common sign Cell immunophenotype resulte displayed 51 2% of the PE NHL originating from T cells,48 8% originating from B cells Most of nasal PE\|NHL originated from T cells ,while most of tonsilla and oral PE\|NHL originated from B cells About half of nasopharyngeal PE\|NHL originated from T cells,another half origiated from B cells Conclusion:The PE NHL in head and neck mostly occurred in nasal cavity ,then occurred in nasopharynx,tonsilla and oral cavity The clinical manifestation in the patients with the PE NHL lacked characteristic symptoms Sometimes these PE NHL were confused with other malignant tumours in primary position,which were easily made a misdiagnosis Therefore discrimination and diagnosis have to be made by pathology and immunohistochemistry
出处
《耳鼻咽喉（头颈外科）》
2001年第2期80-83,共4页
Chinese Arch Otolaryngology-Head Neck Surg
关键词
头颈部肿瘤
淋巴瘤
非霍奇金氏淋巴瘤
Head and neck neoplasms) (Lymphoma) (Non Hodgkin′s lymphoma)
