摘要
目的 :探讨维库溴铵、阿曲库铵对气管平滑肌的直接影响。方法 :用电刺激兔离体气管平滑肌张力的直接影响。结果 :发现略高于临床浓度的维库溴铵 (3× 10 - 6 mol/ L)和阿曲库铵 (10 - 5 m ol/ L)对气管平滑肌张力无显著影响 (P>0 .0 5 ) ;更高浓度的维库溴铵 (3× 10 - 4 mol/ L )可使气管平滑肌收缩力持续增加 (P<0 .0 5 ) ;而高浓度的阿曲库铵 (10 - 3mol/ L )可使气管平滑肌收缩力先一过性增加 ,随后降低 (P<0 .0 5或 P<0 .0 1)。结论 :在离体条件下 ,临床剂量范围内维库溴铵、阿曲库铵不增加气管平滑肌张力 ,但应避免大剂量快速使用。
Objective:To investigate the direct effects of different concentrations of vecuronium and atracurium on the tension of tracheal smooth muscle.Methods: The method of Electrical stimulation was used to induce the change of isolated rabbit tracheal smooth muscle tension.Results:The comcentrations of vecuronium (3×10 -6 mol/L) and of atracurium (10 -5 mol/L) had no effects on the tension of tracheal smooth muscle. But the high concentration of vecuronium (3×10 -4 mol/L) could significaltly increase the smooth muscle tension for 15 min( P <0.05);the tension of smooth muscle atracurium (10 -3 mol/L) at first was significantly increased and then after 15 min significantly decreased. Conclusion:It is suggested that vecuronium and atracurium didn′t increase the isolated tracheal smooth musle tension with the usual clinical doses. But It must be refused in usage of higher doses.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2001年第3期233-234,共2页
Journal of Nanjing Medical University(Natural Sciences)
基金
南京医科大学科研基金资助项目 ( KJD3 2 0 0 0 5)
