摘要
目的 :评价 5 FU对大肠癌化疗的疗效。方法 :通过流式细胞术测定化疗组和对照组患者癌细胞的凋亡指数 (AI) ,S期细胞比率 (SPF)以及抗凋亡基因bcl 2的表达。结果 :化疗组SPF、AI、bcl 2较对照组均有显著性提高 ,经单因素直线相关分析 ,AI和SPF、bcl 2呈正相关。结论 :5 FU是通过细胞凋亡而发挥作用的 ,化疗后AI、SPF和bcl 2均升高 ,它们可作为化疗疗效及预测预后的指标。
Objective:To investigate the effect of 5 FU in treatment of colorectal neoplasm.Methods:Apoptosis index(AI),s phase fraction(SPE) and bcl 2 expression were examined by flow cytometry colorectal neoplasm patients with or without preoperative drug therapy by 5 FU.Results:The study showed that the AI,SPF and bcl 2 expression in drug therapy group increased significantly compared with control group.It also showed the level of AI correlated with the level of SPF and bcl 2 expression.Conclusion:5 FU shows its effects by apoptosis,and AI,SPF,bcl 2 can be used to evaluate the effects of 5 FU and predict prognosis.
出处
《山东医科大学学报》
2001年第2期147-148,共2页
Acta Academiae Medicinae Shandong
