摘要
目的:探讨苦参碱在慢性病毒性肝炎抗肝纤维化中的作用。方法:选择140例慢性乙型肝炎(CHB)病人,分苦参碱组及对照组。分别于治疗前后检测肝功能、病毒指标及肝纤维化血清学指标(HA、PCⅢ、Ⅳ-C、LN)。结果:治疗组治疗后肝纤维化指标均明显下降,HA、PCⅢ、Ⅳ-C、LN分别为112.43±39.18ng/ml、113.33±38.77ng/ml、60.13±19.72ng/ml、95.54±39.08ng/ml,与治疗前及对照组治疗后比较,差异显著(均P<0.01)。结论:苦参碱有明显的抗肝纤维化作用。
Objective: To study the clinical effect of Matrine on serum fibrosis marks hyaluronic acid (HA), procollagen type Ⅲ(PC Ⅲ ),collagen type Ⅳ( Ⅳ-C) and laminin(LN) levels in chronic hepatitis B. Methods: 140 Patients with chronic hepatitis B (CHB) were divided into two groups: Matrine group (80 patients) and the control group (60 patients ). The levels of serum fibrosis marks were proved before and after treatment in two groups. Results: The serum parameters of fibrosis all significantly changed after 3 months of treatment in treated groups (all P<0. 01). Conclusion: Matrine had the effect of antifibrosis.
出处
《中西医结合肝病杂志》
CAS
2001年第2期71-72,共2页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
