摘要
目的 :探讨高压氧 (HBO)对急性缺血性脑中风的治疗价值及机理。方法 :对 40例脑梗塞患者予以HBO加尼莫地平治疗 (HBO组 ) ,40例脑梗塞患者予以尼莫地平加甘露醇治疗 (药物组 ) ,于治疗前后检测红细胞变形指数 (DI)、球结膜微循环 (BCM )、经颅多普勒超声 (TCD)的改变 ,进行对比分析。结果 :HBO组治疗后BCM改善显著 (P <0 .0 1) ,DI明显增强 (P <0 .0 1) ,但TCD无明显变化 (P >0 .0 5 )。药物组治疗后BCM、DI及TCD均较治疗前明显改善 (P <0 .0 5 ) ,BCM、TCD与HBO组比较有明显差异 (P <0 .0 5 )。DI和临床神经功能缺损疗效评价 ,HBO组与药物组比较无显著差异 (P >0 .0 5 )。结论 :HBO在治疗缺血性脑中风方面并不优越于常规药物的疗效 ,它具有双重性 ,既有有利的一面 ,也存在不利的影响 ,必须适当选择适应症 ,并应与扩血管药、钙离子拮抗剂联合使用以对抗其不利的影响 ,有利于缺血脑中风的治疗及康复。
Objective: To evaluate the effect of hypirbaic oxygenation(HBO) for acute ischemic stroke and to discuss the mechanism of HBO therapy.Method: 80 patients with cerebral infarction were divided into two groups:40 in hypirbaic oxygenation(HBO) group(treated by HBO and Nimodipine).40 in control group(treated by Nimodipine and Mannitol).Red cell deformity index(DI),bulbar conjunctiva microcirculation(BCM) and transcranial Doppler(TCD) were detected before and after treatment.Results: After treatment,BCM and DI improved remarkably(P<0.01),but TCD did not show remarkably change(P>0.05) in HBO group.While all these three parameters improved significantly(P<0.05) in control group.BCM,TCD were significantly different between HBO group and control group(P<0.05).There were no remarkable difference between HBO group and control group in DI and evaluation of clinical neural function improvement(P>0.05).Conclusion: As a therapy for ischemic stroke,HBO has its advantage and disadvantage.Cases should be selected and vasodilator,anti-Calcium drugs should be administered at the same time.
出处
《微循环学杂志》
2001年第1期20-21,共2页
Chinese Journal of Microcirculation
关键词
高压氧
药物治疗
急性脑梗塞
红细胞变形
球结膜微循环
Hypirbaic Oxygenation
Ischemic stroke
Bulbar conjunctiva microcirculation
Red blood cell deformity index
Transcranial Doppler
