摘要
目的 :观察养阴通脑颗粒对麻醉犬脑血流量的影响。方法 :将 2 9只犬随机分为 5组 ,养阴通脑颗粒大剂量组(2 .0 g/kg) ;中剂量组 (1.0 g/kg) ;小剂量组 (0 .5 g/kg)及阳性药维脑路通组 (维脑路通 0 .0 2 5 g/kg) ,空白对照组给等量的生理盐水。结果 :养阴通脑颗粒 (0 .5 ,1.0 ,2 .0 g/kg)可增加麻醉犬的脑血流量 ,中剂量组在 30～ 90 m in时增加更明显 ,与维脑路通组比较 ,在 30 min时 ,大、中剂量组的脑血流量比维脑路通组明显 (P<0 .0 5 )。结论 :养阴通脑颗粒扩张脑血管的疗效比小剂量的维脑路通好。
AIM:to study the effect of yangyintongnao particle on cerebral blood flow in anaesthetized dog. METHODS:29 dogs were randomly allocated to five groups. In control group physiological solution was administered with gastrogavage, In other four groups, a large dose of yangyintongnao particle(2 g/kg),a middle dose of yangyintongnao particle(1 g/kg),a small dose of yangyintongnao particle (0.5 g/kg) and weinaolutong pian were administered with gastrogavage respectively. Blood flow of artery carotis interna was detected by electricmagnetic flowmeter. RESUTS: Yangyintongnao particle can increase cerebral blood flow in campare to weinaolutongpian,a middle dose of yangyintongnao particle was remarkable in increasing,cerevral blood flow following administion 30,60 90 min, a middle dose and a large dose of yangyintongnao particle increase cerebral blood flow more than weinaolutong in 30 min. CONCLUSION: Yangyintongnao particle cause cerebral vasodilutation, it was obviously superior than a small dose of weinaolutongpian.
出处
《心脏杂志》
CAS
2001年第2期98-100,共3页
Chinese Heart Journal
基金
国家自然科学基金项目!( No.3 980 0 192 )
关键词
脑血流量
狗
麻醉
养阴通脑颗粒
中药
药理
cerebral blood flow
dogs
anaesthetize
yangyintongnao particle
