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即刻早期基因c-fos与癫 被引量：4

Teh immediate-early gene c-fos and opilepsy
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摘要 c- fos作为即刻早期基因的一种 ,编码的 Fos蛋白组成了其他许多基因的转录调控因子 ,因而可将外界信号级联放大 ,造成细胞长期的生理功能改变。近年来 ,对 c- fos进行了广泛而深入的研究 ,并取得了一定的成果。本文就其结构、功能及其与癫的关系作一综述。 C fos,one of the immediate early genes,encodes Fos,which appears to modulate the express of more “downstream” genes and attribute to long term changes in cellular function.Recently,c fos has been researched on extensively and progress has been acquired greatly.This article summarizes c fos on structure,function and the relationship to epilepsy.
作者 胡志刚 谭启富
机构地区 南京大学医学院临床学院南京军区南京总医院神经外科
出处 《医学研究生学报》 CAS 2001年第2期169-172,共4页 Journal of Medical Postgraduates
关键词 C-FOS 癫痫 基因 C fos Epilepsy Gene
分类号 R742.1 [医药卫生—神经病学与精神病学]
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参考文献19

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  • 2Mamelak AN,Lowenstein.Regulation of gene expression.In:Engel Jr (ed).Epilepsy: A Comprehensive Textbook[M].Philadelphia:Lippincott-Raven Publishers,1997,291-306.
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  • 7Samoriski G,Piekut DT,Applegate CD.Differential spatial patterns of Fos induction following generalized clonic and generalized tonic seizures[J].Exp Neurol,1997,143(2): 255-268.
  • 8Kiessling M,Lutzenburg M,Witte OW,et al.Induction of FOS and JUN proteins during focal epilepsy: congruences with and differences to [14C]deoxyglucose metabolism[J].Brain Res Mol Brain Res,1997,46(1-2): 177-184.
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同被引文献30

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医学研究生学报
2001年 第2期

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