摘要
目的 :探讨钙拮抗剂硝苯地平对牙龈成纤维细胞的作用。方法 :体外培养牙龈成纤维细胞 ,细胞在不同浓度硝苯地平作用下计数观察。结果 :细胞计数在实验第 6、7天出现组间非常显著性差异。主要表现为硝苯地平 12 0 0 μg/L和 36 0 μg/L组 ,细胞计数明显高于低剂量组。 结论
AIM: To investigate the effects of nifedipine, a calcium channel blocker, on cellular proliferation of gingival fibroblasts in vitro . METHODS: Gingival fibroblasts were cultured and incubated with various concentrations of nifedipine(1?200, 360,108 and 23.5μg/L)for 7days. RESULTS: Cell numbers were different significantly among those groups on the sixth and seventh day, especially between 1?200μg/L(or 360μg/L) group and other groups. CONCLUSIONS: Nifedipine can influence the proliferation of gingival fibroblsts at high concentration.
出处
《牙体牙髓牙周病学杂志》
CAS
2001年第1期7-9,共3页
Chinese Journal of Conservative Dentistry
基金
江苏省自然科学基金资助项目
