摘要
目的研究老年高血压病人血清 型前胶原 (PC )的浓度变化及临床意义。方法应用放免法测定 33例 、 期老年高血压患者血清 PC 的含量 ,以 2 0例血压正常的同龄健康人作对照 ;同时对病人行心脏彩色多普勒检查 ,测定左室重量 (L VM)及二尖瓣口舒张早期、舒张晚期最大血流速度 (VE、VA)。结果老年高血压组与对照组比较 ,血清 PC 浓度增高 (P<0 .0 0 1)。在老年高血压病组 ,血清 PC 与 VE/ VA 呈负性相关 (r=- 0 .40 3 4,P<0 .0 5 ) ;与 L VM无相关关系 (r=0 .16 5 8,P>0 .0 5 )。结论在老年高血压病人中 ,血清 PC 参与了高血压的发生、发展过程 ;使心肌硬度增加 ,心肌纤维化 。
Objective To study the changes in concentration of serum procollagen type Ⅲ (PCⅢ) and the correlations between the PCⅢ and cardiac function parameters(V E/V A),left ventricular mass(LVM) in aged essential hypertensive patients.Methods The concentration of PCⅢ was measured by radioimmunoassay in 33 aged essential hypertensive patients and 20 normotensive subjects.At same time,two dimensional M mode Doppler ultrasound examination was made to determine patient's LVM,maximal early transmittal flow velocity(V E) and maximal late transmittal flow velocity(V A).Results The concentration of serum PCⅢ increased in aged essential hypertensives than that in normotensives ( P <0 001).And in aged essential hypertensives,an inverse correlation was found between PCⅢ and V E/V A( P <0 05);but there is no relationship between PCⅢ and LVM( P >0 05).Conclusions PCⅢ involved in the occurrence and development of the essential hypertension,which made myocardium fibrosis and affected cardiac diastolic function.
出处
《中国慢性病预防与控制》
CAS
2001年第2期58-59,共2页
Chinese Journal of Prevention and Control of Chronic Diseases
关键词
高血压
Ⅲ型前胶原
心肌纤维化
心功能
Essential hypertension
Procollagen type Ⅲ
Myocardial fibrosis
Heart function
