摘要
目的:探讨血浆一氧化氮(NO)、内皮素(ET)在原发性高血压(EH)合并高脂血症患者中的临床意义。方法:检测48例EH患者外周静脉血中NO和ET含量,其中21例合并高脂血症(A组);27例不伴高脂血症(B组)。以24例健康查体人群作为对照(C组)。结果:A组患者血浆NO含量均较B组及C组升高(P<0.05,P<0.01),A组血浆ET含量也较B组及C组升高(P<0.01)。结论:EH及合并高脂血症患者血浆NO和ET含量升高是高血压及其高脂血症的重要病理生理变化之一,反映了血管内皮细胞的功能紊乱。
Objective: To investigate the clinical significance of changes in plasma nitric oxide (NO) and endothelin (ET) levels in essential hypertensin (EH) with hyperlipoproteinemia. Methods : Using blood samples obtained from vein, NO and ET levels were determined in 48 patients with EH(21 cases in EH with hyperlipoproteinemia-A group; 27 cease in EH without hyperlipoproteinemia-B group). 24 healthy subjects served as normal controls (C group). Results : Plasma NO levels in A group Was much higher than B group (P<0.05) and, C group (P<0.01). plasma ET levels in A group was much higher than that in B group (P<0.01), C group (P<0.01). Conclusion : The increase in plasma NO and ET might be a pathophysiological characteristic in EH with/without hyperlipoproteinemia, which would deflect endothelial dysfunction of EH.
出处
《医学理论与实践》
2001年第4期294-296,共3页
The Journal of Medical Theory and Practice
关键词
原发性高血压
高脂血症
一氧化氮
内皮素
Essential hypertensi on, Hyperlipoproteine mia, Nitric oxide, Endothelin
