摘要
本文研究了在正常条件下(37℃,pH7.4)培养乳鼠心肌细胞中^(99)Tc-CPI的浓聚和清除。在与37kBq ^(99m)Tc-CPI孵育41.1min时心肌细胞的浓聚达坪值(4291.6cpm/mg cell protein)。其清除分为两个部分:快相半排时间为3.3min;慢相半排时间为198.0min。说明^(99m)Tc-CPI在心肌细胞中的浓聚与被动扩散有关。
The uptake and release of 99mTc-CPI were studied in cultured monolayer neonatal rat myocardial cells incubated under normal condition (37℃, pH 7.4). The plateau level of uptake (4291.6 cpm/mg cell protein) was reached at 41.1 min when incubated with 37 kBq 99mTc-CPI. The 99mTc-CPI release was composed of at least two components. The fast component had a half-time (t1/2) of 3.3min and the slow one had a t1/2 of 198.0 min. It was suggested by the authors that the uptake of 99mTc-CPI by cultured myocardial cells might be related to passive difussion.
出处
《核技术》
CAS
CSCD
北大核心
1991年第11期647-649,共3页
Nuclear Techniques
关键词
心肌细胞
培养
浓聚
清除
Cultured myocardial cells Uptake and release 99mTc-CPI
