摘要
目的 探讨细胞周期相关基因与葡萄膜黑色素瘤病理分型及浸润能力的关系。 方法 采用免疫组化法定量检测 96例葡萄膜黑色素瘤标本中 cyclin D1和 Bcl- 2蛋白的表达。 结果 Bcl- 2在所有葡萄膜黑色素瘤中均有较高表达 ,与病理学分型及巩膜外浸润无关 ;cyclin D1的表达依梭型、混合型、上皮型逐渐增高 ,与肿瘤的浸润能力呈正相关。 结论 bcl- 2的表达对于葡萄膜黑色素瘤细胞的存活具有重要作用 ,cyclin
Objective To evaluate the role of the cell cycle related genes cyclinD1 and Bcl-2 protein expression in the pathogenesis and infiltration of the uveal melanoma. Methods Using immunohistochemistry to detect the cyclinD1 and bcl-2 protein expression in 96 cases of uveal melanoma. Results The expression content of bcl-2 was high in uveal melanoma, and there wasnt any relationship between bcl-2 cell positivity and tumor cell type and extrascleral extension. In contrast, cyclinD1 expression was higher in epithelial cell uveal melanoma than mix cell and spindle cell varieties. There was a positive correlation between cyclinD1 cell positivity and extrascleral extension. Conclusion The expression of bcl-2 protein is important for the survival of the uveal melanoma. CyclinD1 may serve as a sensitive index of its malignancy.
出处
《中华眼底病杂志》
CAS
CSCD
2001年第1期44-46,共3页
Chinese Journal of Ocular Fundus Diseases
关键词
葡萄膜
黑色素
肿瘤
病理生理学
细胞周期
免疫组织化学
Uveal neoplasms/physiopathology
Melanoma/physiopathology
Cell cycle
Immunohistochemistry
