摘要
目的 了解小半夏汤对小鼠胃肠动力改变的影响及其量效关系 ,探讨其防治呕吐的作用机理。方法 (1)小鼠腹腔注射顺铂制作动物模型 .将小鼠随机分为 6组——正常对照组、病理模型组、阳性对照组、小半夏汤高、中、低剂量组。各组均给药 2周 ,半固体营养糊法测定胃排空指标。 (2 )将小鼠随机分为 5组——正常对照组、阳性对照组、小半夏汤高、中、低剂量组。给药 2周 ,墨汁法测定小肠推进指标。结果 小半夏汤用药组胃残留率明显低于模型组 (P<0 .0 1) ,同时显著地降低了小鼠的小肠推进距离 (P<0 .0 5 )。结论 小半夏汤具有调节胃排空 。
Understand the effect and quantity effectiveness relationship of Xiao Banxia Tang on mouse gastric intestinal motive and explore the functional mechanism of its preventing and treating vomiting.Method(1) Inject platinum into mouse abdominal cavity to make animal model. Divide mice randomly into 6 groups,i.e.,normal control, pathological model, positive control, high, middle and low dosage of Xiao Banxia Tang. Give medicine to each group for 2 weeks, measure the gastric emptying quota with half stable nutritious paste method.(2) Divide the mice into 5 groups, i.e., normal control, positive control, high, middle and low dosage of Xiao Banxia Tang. Give them the medicine for 2 weeks, measure the quota of intestinal propulsion with ink method. Result(1) Gastric remaining rates of the groups using Xiao Banxia Tang were markedly lower than that of model one(P<0.01),(2)Xiao Banxia Tang obviously lowered mice intestinal propulsive distance(P<0.05).Conclusion Xiao Banxia Tang could regulate gastric emptying and inhibit intestinal propulsion.
出处
《浙江中医学院学报》
2001年第2期48-49,共2页
Journal of Zhejiang College of Traditional Chinese Medicine
