摘要
以珠江流域鲇鱼 ( Silurus asotus)为实验材料 ,研究了多巴胺 ( DA)能药物 ( DA及其 D-2型受体拮抗物domperidone,DOM)对鲇鱼促性腺激素 ( Gt H)释放的影响 .结果表明 :在性腺发育的各个时期 ,单独注射DOM( 5μg/g)均不能显著提高鲇鱼血液基础 Gt H水平 ,当 DOM与 LHRH-A联合注射时能显著增强LHRH-A刺激 Gt H释放的作用 ;DA只能抑制 Gn RH诱导的 Gt H释放 ,对基础 Gt H释放无抑制作用 .这种生殖内分泌调节方式与鲇形目的革胡子鲇 ( Clariasgariepinus)和大鳍 ( Mystus macropterus)相似 ,而与鲤形目的鲤科 ( Cyprinidae)
The effects of dopamine (DA) and domperidone (DOM), a dopamine D 2 receptor antagonist, on gonadotropin (GtH) release in catfish ( Silurus asotus ) were investigated. DOM failed to stimulate an increase in basal level of serum GtH in different stages of ovarian development, injection of DOM plus LHRH A resulted in significantly higher serum GtH level than control groups.DA failed to inhibit the basal level of serum GtH, but blocked GtH release induced by GnRH. These results suggested that the neuroendocrine regulation of GtH release in catfish is different from goldfish ( Carassius auratu ) and common carp ( Cyprinus carpio ), but similar to that of African catfish ( Clarias gariepinus ) and bagrid catfish ( Mystus macropterus ).
出处
《生命科学研究》
CAS
CSCD
2001年第1期84-87,共4页
Life Science Research
基金
国家自然科学基金资助项目!(39970 5 86 )
关键词
鲇鱼
促性腺激素
多巴胺
地欧酮
内分泌调节
catfish( Silurus asotus )
gonadotropin (GtH)
dopamine (DA)
domperidone (DOM)
