摘要
在能量代谢和自由基代谢中 ,线粒体均占据着十分重要的地位 .通过呼吸链电子漏途径 ,线粒体产生大量超氧阴离子 ,并通过链式反应形成对机体有损伤作用的活性氧 .通过呼吸链电子漏 ,氧化磷酸化解偶联 ,线粒体内膜产生通透性转变孔道 (PTP)及Box 和 /或PTP 介导的细胞色素c向胞质的转移等种种因素 ,线粒体参与一般抗氧化防御及细胞凋亡等重要生理过程的调控 .在与线粒体相关的细胞凋亡中 ,活性氧的信号作用是十分明显的 .
Mitochondria are involved not only in energy metabolism but also in free radical metabolism. Superoxide anion can be generated through a way of electron leak of respiratory chain and the reactive oxygen species (ROS) can be formed in the further reactions of O-2(radical anion) in mitochondria. The role of mitochondria in antioxidant functions and cell apoptosis is discussed in terms of electron leak of respiratory chain, uncoupling of oxidative phosphorelation, mitochondrial pore, Box- or/and PTP-mediated release of cytochrome c from mitochondria and so on. The signaling act of ROS is emphasized in the regulation of cell apoptosis.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2001年第2期168-171,共4页
Progress In Biochemistry and Biophysics
关键词
线粒体
活性氧
细胞凋亡
电子漏
细胞色素C
mitochondria
reactive oxygen species
apoptosis
electron leak
cytochrome c
