摘要
由于世界环境污染日趋严重,环境的医学防护已成为世界瞩目的研究课题。环境医学的发展需要不断总结在有害环境因素作用下机体的变化规律,但迄今为止,在环境医学中,只有Selye的应激理论作为有指导性的、整体反应模式。本文总结了在过去十年我们实验室研究中经常出现的另一种整体性反应模式,这种整体性反应模式往往在环境有害因素长期或重复作用下出现。在我们过去的研究中,当微波,电离辐射,高浓度二氧化碳,噪声和抗癌药物长期作用于人体或小鼠时,即出现整体性生理功能抑制现象,其表现有:白细胞和血小板明显减少,各种免疫指标降低,大脑、脾脏、血液等组织的血清素含量减少,并出现全身性体力虚弱的症状(全身乏力,记忆力减退,食欲不振,畏寒等)。与此同时,并不像Selye在应激的警觉反应(Alarm reaction)和衰竭期(stage of exhaustion)中所表述的那样,糖皮质激素含量是增加的,而相反却是降低的,肾上腺亦出现萎缩。因此在环境有害因素作用下应该存在着另一种整体性反应类型——我们称之为整体性抑制症候群。由于抑制症候群与中医的虚证有类似之处,我们实验室曾用滋阴补阳类中药治疗,亦取得明显疗效。文中并讨论了在老年期和在某些疾病时可能出现的与抑制症候群相似的表现。
The paper summarized the characteristic manifestations caused by long—term or repeated exposures of human subjects and mice to adverse environmental factors. The results from exposure to microwave, irradiation, high concentration of CO_2 and chemical drugs showed general depression of bodily functions: i.e., asthenic changes of general conditions, depression of immune functions and hematopoiesis, and disturbance of serotonin secretion in certain organs. In the meantime, the glucocorticoid secretion was reduced instead of being enhanced as shown in the alarm reaction and the exhaustion stage of stress described by Selye. As a reaction pattern to various environmental factors, the above mentioned depression syndrome is different from Selye's general adaptation syndrome. Possible presence of the depression syndrome in senile persons and in the chronic diseases were also discussed.
出处
《航天医学与医学工程》
CAS
CSCD
1991年第2期79-84,共6页
Space Medicine & Medical Engineering
关键词
环境因素
抑制症侯群
血清素
免疫
environmental facfors, depression syndrome, immune functions, serotonine
