摘要
目的 应用超选择髂内动脉化疗治疗妇科恶性肿瘤并观察其疗效及副作用。方法 采用Seldinger’s改良法经皮股动脉穿刺行超选择髂内动脉化疗及栓塞治疗妇科晚期恶性肿瘤 36例 ,其中卵巢癌 16例、宫颈癌 13例、阴道癌 3例、子宫内膜癌 2例、绒癌及子宫平滑肌肉瘤各 1例。共进行 48次超选择髂内动脉化疗 ,其中同时进行双侧超选择髂内动脉栓塞 31次、肠系膜下动脉化疗 13次、肝固有动脉栓塞 2次、卵巢动脉栓塞 1次。结果 完全缓解 4例 ,部分缓解 2 3例 ,无变化 5例 ,进展 4例 ,总有效率 75 %。其副反应主要为轻度消化道反应及栓塞综合症 ,无插管并发症。结论 超选择技术直接向肿瘤供血动脉注射化疗药物 ,局部浓度高 ,疗效好 ,副反应低。术前化疗疗效优于术后盆腔复发者 ;宫颈癌、子宫内膜癌及阴道癌优于卵巢癌。
Objective To study the effects of super selected internal iliac artery incubation in the treatment of advanced gynecological malignant tumors. Methods 36 cases of advanced gynecological malignant tumors (16 ovarian carcinoma, 13 cervical carcinoma, 3 vaginal carcinoma, 2 endometrial carcinoma, 1 choriocarcinoma and 1 leiomyosarcoma of uterus) were treated with this method for 48 times. 31 of these 48 times were embolized in bilateral iliac arteries, 13,2 and 1 cases the inferior mesenteric artery, the hepatic proper artery and the ovarian artery were embolized respectively. Results 4 cases showed complete response, 23 showed partial response, no change in 5 cases and in the rest 4 cases the disease was still in progress. The main side effects were slight gastro intestinal reactions and embolism symptoms but no incubation complication occurred. Conclusion The super selected artery of incubation will give high local density of chemotherapeutic drugs and low concentration in general circulation. The effects are better in cervical, endometrial and vaginal carcinomas than in ovarian carcinoma.
出处
《肿瘤》
CAS
CSCD
北大核心
2001年第2期140-141,共2页
Tumor
