摘要
利用“成石饲料”喂养仓鼠,建立胆囊结石模型,用扫描和透射电镜观察到胆囊粘膜上皮的变化和粘蛋白颗粒与胆固醇结晶的出现,证实了胆囊在胆结石发生中的重要作用。
To study the effect of gallbladder mucosa upon gallstone formation, we fedhamsters with lithogenic diet and observed the process of gallstone formation bylight, transmission and scanning electron microscope. The most predominant change was that glycoproteins were found on thesurface of epithelial cells before crystallization and increased markedly at thebeginning of crystallizaton and stone formation. Transmission and scanning electronic microscopy showed a series of degener-ative changes in the epithelial cells, beginning with isolated cells of varyingsizes, enlargement and adhesion of microvilli to each other. The increasedsecretion of mucus and the change in the gallbladder surface suggested thatgallbladder mucosa offered a preferable site for the crystallization of cholesteroland for the combination and growth of these crystals. The mucus secreted from gallbladdder mucosa is the decisive substance in gallstone formation.
出处
《中国医科大学学报》
CAS
CSCD
1990年第1期54-56,共3页
Journal of China Medical University
