摘要
A series of aromatic cyanohydrins and their O silyl ethers have been synthesized by trimethylsilylcyanation of aromatic aldehydes using a catalyst generated in situ from optically active R (+) 1,1 2 bisnaphthol with n butyl lithium. Mandelonitrile was prepared in an isolated yield 70% with more than \{e.e.\} =60%. The effect of solvents and the amount of catalyst on enantioselectivity was also investigated.
A series of aromatic cyanohydrins and their O silyl ethers have been synthesized by trimethylsilylcyanation of aromatic aldehydes using a catalyst generated in situ from optically active R (+) 1,1 2 bisnaphthol with n butyl lithium. Mandelonitrile was prepared in an isolated yield 70% with more than \{e.e.\} =60%. The effect of solvents and the amount of catalyst on enantioselectivity was also investigated.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2001年第4期601-602,共2页
Chemical Journal of Chinese Universities
基金
国家自然科学基金! (批准号 :2 9972 0 16)
香港理工大学手性科技开放实验室基金
甘肃省自然科学基金资助
