摘要
我们已经报道了同时带有咪唑基、羧基和羟基三种功能团的糖淀粉衍生物（CHA）能有效地催化N－十二烷基－3－乙酰氧基吡啶盐碘化物（DAPI）的水解，并推断出反应系在螺旋端部进行，如果受物的反应部位进入了螺旋内穴，情况又会怎样呢？本工作通过作用三种不同的受物，N－十二烷基－2－氯代吡啶盐碘化物（DCPI，1），N－十二烷基－3－乙酰氧基吡啶盐碘化物（DAPI，2）和对硝基苯酚月桂酸酯（PNPL，3）和改变粮淀粉链上悬挂功能团的尺寸来回答上述问题。
The different effects of some amylose derivatives on the hydrolysis of N-dodecyl-2-
chloropyridinium iodide (1) and p-nitrophenyl laurate (3) have been studied. Either
aminoethylamylose (AEA) or imidazole catalyzes the hydrolysis of 1, but
carboxymethylhistaminoacylmethylamylose (CHA) inhibits the reaction. This result
could be attributed to the size differential beitween amino and imidazole groups, in same
way, carboxymethyldiaminoethylacylmethylamylse (CAA) catalyzes the hydrolysis of a
neutral substrate 3 much efficiently than CHA. From the study of degree of substitution
in CHA on hydrolysis of N-dodecyl-3-acetyloxypyridinium iodide (2), a same conelusion
from enzyme catalysis that a loose complex between host and substrate possesses heigher
catalytic efficiency can be derived based on this model system.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
1989年第8期824-826,共3页
Acta Chimica Sinica
