摘要
目的 考察黄芩苷与磷脂形成复合物后的理化性能变化。方法 对研制的黄芩苷磷脂复合物的晶体特征、相变特征、水分散性质、溶解性能及油 水分配系数进行了研究。结果 X 射线衍射分析显示 ,复合物呈现无定型特征 ;差示扫描显示复合物的相变温度降低 ;还观察到复合物在水中分散呈胶团状 ,与脂质体类似 ;黄芩苷磷脂复合物明显改善了黄芩苷在水及正辛醇中的溶解性能 ;在不同pH水 正辛醇系统中 ,黄芩苷磷脂复合物的表观油 水分配系数与黄芩苷相比也有较大的差异。结论 与黄芩苷相比 。
OBJECTIVE To study the physico chemical properties of baicalin phospholipid complex.METHOD The apparent solubility,oil/water partition coefficients, crystal characteristics and other properties were investigated.RESULTS It was shown great improvements of the apparent solubility of baicalin phospholipid complex both in water and in n octyl alcohol.Some differences of apparent oil/water partition coefficients in the systems consisted of different pH water and n octyl alcohol were found between the complex and baicalin.The spectra of X ray diffraction indicated that the complex exhibited an amorphous characteristics and the crystal diffraction peaks of baicalin disappeared completely.A shift of the main transition of DPPC to a lower temperature was observed in the DSC spectrum of the complex.CONCLUSION The physico chemical properties of baicalin phospholipid complex were greatly different from those of Baicalin.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2001年第3期173-177,共5页
Chinese Pharmaceutical Journal
基金
国家自然科学基金资助项目!(395 70 85 9)
关键词
黄芩苷
磷脂复合物
理化性能
baicalin
phospholipid complex
physico chemical properties
