摘要
目的 证实钩端螺旋体外膜菌苗的安全性和免疫效果。方法 在湖北省荆州市和石首市现场接种钩端螺旋体外膜菌苗 80 0 0 0人份 ,观察 48h内体温、局部红肿等副反应和一年内接种钩端螺旋体外膜菌苗者发病情况 ,同时设对照组。结果 所有钩端螺旋体外膜菌苗接种者未见严重副反应和异常反应 ,仅 2例菌苗接种者有低热和局部红肿 ,48h后消失 ,安全性良好。接种组发生黄疸出血群钩端螺旋体病人 2例 ,对照组发生黄疸出血群钩端螺旋体病人 47例 ,黄疸出血群钩端螺旋体外膜菌苗保护效果 95 .5 7% ,95 %可信限为 85 .43%～ 98.2 0 % ;对照组发生七日热群钩端螺旋体病人 15例 ,七日热群钩端螺旋体外膜菌苗有效率 10 0 .0 0 % ,95 %可信限下限 77.0 8%。结论 钩端螺旋体外膜菌苗安全性良好 ,接种与疫区流行菌群一致的钩端螺旋体外膜菌苗 。
Objective To study the safety and effect of Leptospiral outer membrane vaccine. Methods Eighty thousands dosages of Leptospiral outer membrane vaccine were vaccinated in Jingzhou and Shishou city Hubei prevince. Temperaure, side effects such as Local edema with in 48 hours as well as the incidence of Leptospirsis within a year among those were vaccinated and unvaccinated were observed. Results (1)No any severe side effect and abnormal reaction, was found, only 2 case suffered from slight fever and local edema which receded in 48 hrs. (2) Effects of Leptospiral outer membrane vaccine were as follows: 2 cases were attacked by lcterohaemorrhagiae in vaccination group and 47 cases in control group, so the protection rate 95.57 % and confidence interval (CI) was 85.43 % 98.20 %. Fifteen hebdomadis cases were found in control group. The protection rate of this vaccine reached 100.00 %, CI 77.08 % 100.00 %. Conclusion Safty and protective effect were well showed when type of bacteria was concordant with that in vaccination district.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2001年第2期108-110,共3页
Chinese Journal of Epidemiology
