摘要
目的 探讨梅尼埃病 (Meniere′sdisease)患者与组织相容性白细胞抗原 (histocompatibilityleukocyteantigen ,HLA) II类基因DRB1等位基因的关联。方法 采用聚合酶链反应 序列特异性引物(polymerasechainreaction sequencespecificprimers,PCR SSP)技术。测试 6 0例梅尼埃病患者和 85名健康人对照。结果 患者组HLA DRB1 3+ 5 + 6 + 8基因组集团总数高于健康对照组 ,相对危险性为 1.99 ,P <0 .0 5 ,患者组HLA DRB1 0 9明显低于健康对照组 ,相对危险性为 0 .17,P <0 .0 1。结论 梅尼埃病患者HLA DRB1 0 9显著下降 ,提示HLA DRB1 0
Objective To investigate the relation between histocompatibility leukocyte antigen (HLA) class II DRB1 and Meniere′s disease in Chinese. Methods Polymerase chain reaction sequence specific primers(PCR SSP)technique was used. HLA class II allele distribution were measured in 60 patients with Meniere′s disease, in comparison with those in 85 normal population. Result The results showed that the frequency of DRB1*09 allele was significantly lower in Meniere′s disease patients than in those of controls(relative risk= 0.17, P <0.01). Conclusion HLA DRB1*09 of the patients with Meniere′s disease was significant low. It implied that DRB1*09 may be a protective gene for Meniere′s disease.
出处
《中华耳鼻咽喉科杂志》
CSCD
北大核心
2001年第1期25-27,共3页
Chinese Journal of Otorhinolaryngology
