摘要
目的 探讨 Fas、Fas L及 p5 3在视网膜母细胞瘤中的表达及意义。方法 用 S- P方法检测 45例视网膜母细胞瘤及 12例正常视网膜组织中 Fas、Fas L及 p5 3蛋白的表达。结果 Fas在视网膜母细胞瘤组织及正常视网膜组织中均呈低表达 ,差异无显著性 (P>0 .0 5 ) ;Fas L在视网膜母细胞瘤及正常视网膜组织中均呈高表达 ,差异无显著性 (P>0 .0 5 ) ;p5 3在视网膜母细胞瘤中的表达较强 ,而在正常视网膜组织中的表达极弱 ,差异有极显著性 (P<0 .0 0 2 )。结论 Fas L在视网膜母细胞瘤及正常视网膜中均呈现高表达 ,与肿瘤细胞的免疫逃逸机制有关 ;突变型 p5 3在视网膜母细胞瘤中的表达明显高于正常视网膜组织 ,可能抑制肿瘤凋亡的发生 ,促进肿瘤的生长。
Objective To investigate the siginificance of Fas/FasL and p53 expression in retinoblastoma.Methods FasL,Fas and bcl 2 were detected immunohistochemically in 45 cases of retinoblastoma and 12 cases of normal retina.Results The expression of Fas in retinoblastoma and normal retina were very low with no difference( P >0.05).The expression of FasL in retinoblastoma and normal retina were high,but with no significantly difference( P >0.05).p53 was highly expressed in retinoblastoma and low expressed in normal retina,with significant difference( P <0.0002).Conclusion High expression of FasL and low expression of Fas in retinoblastoma and normal retina suggested that they might be associated with immune escape.The high expression of p53 in retinoblastoma was closely associated with the tumor development.\;
出处
《实用肿瘤杂志》
CAS
北大核心
2001年第2期97-99,共3页
Journal of Practical Oncology
